About This Project

Protein misfolding and aggregation are involved in neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. Similar, but minor patterns have been observed in normal biological aging without pathology markers. Are those diseases “intensified” variants of “normal” aging events? Can protein dysregulation be manipulated to improve the health of the diseased, or improve the quality of life of an elder?  We study aging and protein aggregation in Caenorhabditis elegans, a small, translucent, short -lived worm. We subject worms to stressors, including emerging environmental contaminants, to study the relationship between premature aging and protein trafficking in cells.  

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